• Julian Simpson

Are you lacking Vitamin D? Because if may be causing you pain

Are you lacking Vitamin D? Because if may be causing you pain


New research looking into low back pain and vitamin D levels have shown interesting preliminary results

They have decided ( November 2021) that patients with non specific low back pain had lower Vitamin D levels and higher inflammatory markers

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Reference

Relationship between Vitamin D and Nonspecific Low Back Pain May Be Mediated by Inflammatory Markers.

Xu HW, Zhang SB, Yi YY, Chen H, Hu T, Wang SJ, Wu DS. Pain Physician. 2021 Nov;24(7):E1015-E1023.

Results: Mean serum concentrations of vitamin D in the control, Ns-ALBP, and Ns-CLBP groups were 25.70 ± 10.04, 21.44 ± 8.46 and 18.25 ± 8.05 ng/mL, respectively (P < 0.001). After adjustment for clinical factors, vitamin D deficiency was associated with Ns-LBP (P < 0.05); however, when the interleukin 6 (IL-6) level was added to the multivariable models, the association was no longer significant in Ns-CLBP patients. Mediation analysis estimated the overall mediated effect as -0.461 (P < 0.001) in Ns-CLBP patients, and the intermediary effect of IL-6 was 0.045.

Limitations: A retrospective study may include inevitable bias. More sensitive biomarkers were not investigated in this study. Pain intensity evaluation using the visual analogue scale is inevitably subjective.

Conclusion: Patients with Ns-LBP had lower vitamin D and higher inflammatory marker levels. This association between hypovitaminosis D and Ns-CLBP may be mediated by IL-6. Therefore, large-scale clinical trials are warranted to investigate the clinical efficacy of vitamin D supplementation for decreasing inflammation and relieving Ns-LBP.

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